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Gajjela, B.K., & Zhou, M.-M. (2021) Calming the Cytokine Storm of COVID-19 Through Inhibition of JAK2/STAT3 Signaling. Drug Discovery Today, S1359-6446(21)000454-2. PMID: 34743903.
Cheung, K.L., Kim, C., & Zhou, M.-M. (2021) The Functions of BET Proteins in Gene Transcription of Biology and Diseases. Frontiers in Molecular Biosciences, 8:728777. PMID: 34540900.
Martinez-Ortiz, W., & Zhou, M.-M. (2020) Could PROTACs Protect Us from COVID-19? Drug Discovery Today, 25 (11): 1894-6. PMID: 32889063.
Han, X.Y., Yu, D., Gu, R.R., Jia, Y.J., Wang, Q., Yang, X.L., Yu, M.M., Babault, N., Zhao, C.C., Yi, H.F., Zhang, Q., Zhou, M.-M., & Zeng, L. (2020) Roles of BRD4 Short Isoform in Phase Separation for Active Gene Transcription. Nature Struct. & Mol. Biol., 27(4):333-341. PMID: 32203489.
Rodríguez-Fernández, Y., Gerona-Navarro, G., Osman, R., & Zhou, M.-M. (2020) In silica Design and Molecular Basis of the Selectivity of Olinone Towards to the First over the Second Bromodomain of BRD4. Proteins, 88(3): 414-430.
Zaware, N., & Zhou, M.-M. (2019) Bromodomain Biology and Drug Discovery. Nature Struct. & Mol. Biol., 26(10): 870-879. doi: 10.1038/s41594-019-0309-8. PMID: 31582847.
Liu J, Duan Z, Guo W, Zeng L, Wu Y, Chen Y, Tai F, Wang Y, Lin Y, Zhang Q, He Y, Deng J, Stewart RL, Wang C, Lin PC, Ghaffari S, Evers BM, Liu S, Zhou MM, Zhou BP, & Shi J. (2018) Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer. Nature Communications, 9(1): 5200. doi: 10.1038/s41467-018-07258-y. PMID: 30518851
Zhang S, Zhao Y, Heaster TM, Fischer MA, Stengel KR, Zhou X, Ramsey H, Zhou MM, Savona MR, Skala MC, & Hiebert SW. (2018) BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML. J Cell Biochem., 2018 Nov 11. doi: 10.1002/jcb.28005. PMID: 30417424
Vincek AS, Patel J, Jaganathan A, Green A, Pierre-Louis V, Arora V, Rehmann J, Mezei M, Zhou MM, Ohlmeyer M, & Mujtaba S. (2018) Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3. Molecules, 23(8). pii: E1930. doi: 10.3390/molecules23081930. PMID: 30072621
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Martín-Martínez M, Pérez-Gordillo FL, Álvarez de la Rosa D, Rodríguez Y, Gerona-Navarro G, González-Muñiz R, & Zhou MM. (2017) Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects. J Med Chem., 60(7): 2629-2650. doi: 10.1021/acs.jmedchem.6b01065. PMID: 28051871
Li J, Rodriguez Y, Cheng C, Zeng L, Wong EY, Xu CY, Zhou MM, & Xu PX. (2016) EYA1’s Conformation Specificity in Dephosphorylating Phosphothreonine in Myc and Its Activity on Myc Stabilization in Breast Cancer. Mol Cell Biol., 37(1). pii: e00499-16. Print 2017 Jan 1. PMID: 27795300
Meslamani J, Smith SG, Sanchez R, & Zhou MM (2016) Structural features and inhibitors of bromodomains. Drug Discov Today Technol., 19:3-15. doi: 10.1016/j.ddtec.2016.09.001. Review. PMID: 27769355
Zhang Q, Zeng L, Zhao C, Ju Y, Konuma T, & Zhou MM. (2016) Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain. Structure, 24(9):1606-12. PMID: 27545619
Zhang Q, Zeng L, Shen C, Ju Y, Konuma T, Zhao C, Vakoc CR, & Zhou MM (2016) Structural Mechanism of Transcriptional Regulator NSD3 Recognition by the ET Domain of BRD4. Structure, 24(7):1201-8. PMID: 27291650
Ren C, Smith SG, Yap KL, Li S, Li J, Mezei M, Vincek AS, Aguilo F, Walsh MJ, & Zhou MM (2016) Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7. ACS Med. Chem. Lett., 7(6): 601–605. PMID: 27326334
Zhang G, Smith SG, & Zhou MM. (2015) Discovery of Chemical Inhibitors of Human Bromodomains. Chem Rev. 115(21):11625-68. PMID: 26492937
Bansal N, Petrie K, Christova R, Chung CY, Leibovitch BA, Howell L, Gil V, Sbirkov Y, Lee E, Wexler J, Ariztia EV, Sharma R, Zhu J, Bernstein E, Zhou MM, Zelent A, Farias E, & Waxman S. (2015) Targeting the SIN3A-PF1 interaction inhibits epithelial to mesenchymal transition and maintenance of a stem cell phenotype in triple negative breast cancer. Oncotarget. 6(33):34087-105. PMID: 26460951
Kwon YJ, Petrie K, Leibovitch BA, Zeng L, Mezei M, Howell L, Gil V, Christova R, Bansal N, Yang S, Sharma R, Ariztia EV, Frankum J, Brough R, Sbirkov Y, Ashworth A, Lord CJ, Zelent A, Farias E, Zhou MM, & Waxman S. (2015) Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer. Mol Cancer Ther., 14(8):1824-36. PMID: 26078298
Stratikopoulos EE, Dendy M, Szabolcs M, Khaykin AJ, Lefebvre C, Zhou MM, & Parsons R. (2015) Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy. Cancer Cell, 27(6):837-51. doi: 10.1016/j.ccell.2015.05.006. PMID: 26058079
Ren C, Morohashi K, Plotnikov AN, Jakoncic J, Smith SG, Li J, Zeng L, Rodriguez Y, Stojanoff V, Walsh M, & Zhou MM. (2015) Small-Molecule Modulators of Methyl-Lysine Binding for the CBX7 Chromodomain. Chem Biol., 22(2): 161-168. pii: S1074-5521. PMID: 25660273
Di Micco R, Fontanals-Cirera B, Low V, Ntziachristos P, Yuen SK, Lovell CD, Dolgalev I, Yonekubo Y, Zhang G, Rusinova E, Gerona-Navarro G, Camero M, Ohlmeyer M, Aifantis I, Zhou MM,Tsirigos A, & Hernando E. (2014) Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes. Cell Rep., 9(1):234-47. PMID: 25263550
Marmorstein R, & Zhou MM. (2014) Writers and readers of histone acetylation: structure, mechanism, and inhibition. Cold Spring Harb Perspect Biol., 6(7):a018762. PMID: 24984779
Gacias M, Gerona-Navarro G, Plotnikov AN, Zhang G, Zeng L, Kaur J, Moy G, Rusinova E, Rodriguez Y, Matikainen B, Vincek A, Joshua J, Casaccia P, & Zhou MM. (2014) Selective chemical modulation of gene transcription favors oligodendrocyte lineage progression. Chem Biol., 21(7):841-54. PMID: 24954007
Smith SG, Sanchez R, & Zhou MM. (2014) Privileged Diazepine Compounds and Their Emergence as Bromodomain Inhibitors. Chem Biol., 21(5):573-583. PMID: 24746559
Zeng L, Kuti M, Mujtaba S, & Zhou MM. (2014) Structural insights into FRS2α PTB domain recognition by neurotrophin receptor TrkB. Proteins, 82(7):1534-41. PMID: 24470253
Liu R., Zhong Y., Li X., Chen H., Jim B., Zhou M-M., Chuang PY., & He JC. (2014) Role of Transcription Factor Acetylation in Diabetic Kidney Disease. Diabetes, 63(7):2440-53. PMID: 24608443
Meslamani, J., Smith, S.G., Sanchez, R., & Zhou, M.-M. (2014) ChEpiMod: A Knowledgebase for Chemical Modulators of Epigenome Reader Domains. Bioinformatics, 30(10):1481-1483. PMID: 24470572.
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Plotnikov, A.N., Yang, S., Zhou, T.J., Rusinov, E., Frasca, A., & Zhou, M.-M. (2014) Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Tandem Module of Human Transcriptional Co-activator CBP. Structure, 22(2): 353-360. PMID: 24361270.
Zhang, G., Plotnikov, A.N., Rusinova, E., Shen, T., Morohashi, K., Joshua, J., Zeng, L., Mujtaba, S., Ohlmeyer, M., & Zhou, M.-M. (2013) Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains. Journal of Medicinal Chemistry, 56(22):9251-64. PMID: 24144283. PMCID: PMC3894848.
Wu, H., Moshkina, N., Min, J., Zeng, H., Joshua, J., Zhou, M.-M., & Plotnikov, A.N. (2012) New Mechanistic Insights into Substrate Specificity and Catalysis of Human Histone acetyltransferase 1 from the HAT1-Acetyl CoA-Histone H4 Ternary Complex Structure. Proc. Natl. Acad. Sci. USA. 109(23):8925-30. PMID: 22615379. PMCID: PMC3384170.
Zhang G, Sanchez R, & Zhou MM (2012) Scaling the druggability landscape of human bromodomains, a new class of drug targets. J. Med. Chem. 55(17):7342-5.
Zhang G, Liu R, Zhong Y, Plotnikov AN, Zhang W, Zeng L, Rusinova E, Gerona-Nevarro G, Moshkina N, Joshua J, Chuang PY, Ohlmeyer M, He JC, Zhou MM (2012) Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J. Biol. Chem. 287(34):28840-51.
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Chakravarty, S., Zeng, L., & Zhou, M.-M. (2009) Structure and Site-Specific Recognition of Histone H3 Lysine 4 by the PHD Finger of Human AIRE. Structure. 7(5):670-9.
Mujtaba, S., Manzur, K.L., Gurnon, J.R., Kang, M., Van Etten, J.L., & Zhou, M.-M. (2008) Epigenetic Transcriptional Repression of Cellular Genes by a Viral SET Protein. Nature Cell Biology, 10, 1114-1122.
Zeng, L., Yap, K.L., Ivanov, A.V., Wang, X., Mujtaba, S., Plotnikova, O., Rauscher, F.J., & Zhou, M.-M. (2008) Structural Insights into the Functional Cooperativity of the Tandem PHD Finger-Bromodomain of Human KAP1 in Sumoylation-Dependence Gene Silencing. Nature Structural & Molecular Biology, 15, 626-633.
Zeng, L., Zhang, Q., Gerona-Navarro, G., Moshkina, N., & Zhou, M.-M. (2008) Structural Basis of Site-Specific Histone Recognition by the Bromodomains of Human Coactivators PCAF and CBP/p300. Structure, 16, 643-652.
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Pan, C., Mezei, M., Mujtaba, S., Muller, M., Zeng, L., Li, J.M., Wang, Z.Y., & Zhou, M.-M. (2007) Structure-Guided Optimization of Small Molecules Selectivity Inhibiting Human Immunodeficiency Virus 1 Tat Association with the Human Coactivator p300/CREB Binding Protein-Associated Facor. Journal of Medicinal Chemistry, 50, 2285-2288.
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Sachchidanand, Resnick-Silverman, L., Yan, S., Mutjaba, S., Liu, W.-J., Zeng, L., Manfredi, L., & Zhou, M-.M. (2006) Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association. Chemistry & Biology, 13, 81-90; featured by Nature Reviews in Drug Discovery in March 2006.
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